Tubulointerstitial nephritis and uveitis (TINU) syndrome: epidemiology, diagnosis and management
نویسندگان
چکیده
Acute tubulointerstitial nephritis is demonstrated in 2–3% of all native renal biopsies, increasing to 10–15% if the biopsy is performed in the setting of acute renal failure [1]. It is most commonly related to medication or infection [1,2]. An increasingly recognized entity is tubulointerstitial nephritis with uveitis (TINU) syndrome. We outline the clinical course of a patient with TINU syndrome and review the changes in epidemiology, diagnosis and management.
منابع مشابه
A Rare Case of Tubulointerstitial Nephritis and Uveitis Syndrome Treated with a Multi-Specialty Approach
BACKGROUND It is important for an ophthalmologist and nephrologist to look for hidden causes of uveitis and nephritis, respectively. Delay in diagnosis leads to increased morbidity and failure to systemically manage the patient results in future recurrence of disease. It is likely that TINU remains underdiagnosed and could potentially account for some of the cases of idiopathic uveitis, especia...
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Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare disease entity usually occurring in children. In the present study a case of TINU syndrome in an elderly patient is described and relevant literature is reviewed. A 61-year-old man presented with bilateral flank pain, urinary frequency, and foamy urine. A kidney ultrasonography revealed an increase in kidney parenchyma echogenic...
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Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare oculorenal inflammatory condition that was first described in 1975. In 2001 a major review identified 133 cases in the world literature and proposed key diagnostic criteria for the condition. Although acknowledged as rare, the limited data available prevented reliable estimates of the prevalence of the condition, and hampered el...
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Firstly, it is controversial to define the second case as tubulointerstitial nephritis (TIN) or TINU syndrome due to lack of either histopathological analysis, or renal failure or uveitis. Despite spontaneous regression of renal findings, it is invalid to diagnose TIN without a biopsy. A similar clinical course may be seen in various other renal disorders related to tubules. It has been reporte...
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BACKGROUND AND OBJECTIVES Tubulointerstitial nephritis and uveitis (TINU) syndrome is considered a rare cause of acute tubulointerstitial nephritis (ATIN) that is usually associated with renal recovery. This study sought to investigate the diagnosis, prognosis, and contributing factors of TINU syndrome using a large cohort of patients with prospective follow-up. DESIGN, SETTING, PARTICIPANTS,...
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